Topic: Neuronal RNA signatures

Seminar: 1 seminar

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Neuroscience

SeminarNeuroscience

Neuronal RNA signatures: Regulation and Function

Valérie Hilgers, PhD

Max-Planck-Institute of Immunobiology and Epigenetics; Freiburg, Germany

Jan 19, 2022

Neurons are uniquely complex cells characterized by the expression of RNA sequences that are found in no other cell type: neuron-specific mRNA splice isoforms, circular RNAs, microRNAs, and ultra-long 3’UTRs. Although relatively little is known about how these neuronal RNA signatures control neuronal development and function, the importance of RNA-directed regulation in the brain is exemplified by its implication in neurological diseases. Our goal is to gain mechanistic and functional insight of the neuron-specific RNA landscape that drives neural function in health and disease.