Topic: neuronal silencing

Apoptosis, a programmed, non-inflammatory type of cell death, is a key homeostatic mechanism in all organisms. In the nervous system of rodents, pronounced apoptotic neuronal loss takes place during the first days of life, and early neuronal activity is one of the essential factors regulating this process.The project aimed to investigate the effects of local neuronal silencing on postnatal apoptosis and cortical activity. New-born mice were implanted with drug-loaded polymers to achieve local and chronic neuronal inactivation in the somatosensory cortex. Subsequent combination of in vivo elect