Hypoxia induces MEK/ERK signaling via primary cilia and the hypoxia-inducible factor-2alpha - a helping factor for neuronal cells to survive ischemia?
Tristan Leu, Jannik Denda, Anna Wrobeln, Joachim Fandrey · FENS Forum 2024
Primary cilia receive extracellular signals and transmit them to the interior implementing signal transduction. These organelles enable the cell to communicate and realize essential processes such as proliferation and migration. Disruption of primary cilia signaling will lead to a multitude of human diseases called ciliopathies. Ciliopathies are often linked to malformations of the central nervous system. Abnormalities in cilia length are a parameter for inadequate function of primary cilia. Especially in situations when oxygen supply falls short, e.g. during an ischemic stroke, it is necessar
ePoster · Neuroscience