Brain-wide microstrokes affect the stability of memory circuits in the hippocampus
Hendrik Heiser, Filippo Kiessler, Adrian Roggenbach, Martin Wieckhorst, Fritjof Helmchen, Julijana Gjorgjieva, Anna-Sophia Wahl · FENS Forum 2024
Cognitive decline after multiple brain-wide microstrokes is reported regularly in patients diagnosed with vascular dementia. However, the neuropathological mechanisms linking microstrokes to cognitive decline remain unclear, with no specific treatment options available. We present a mouse model to study hippocampal memory circuits in the healthy condition and after induction of cerebral microstrokes via microsphere injections. Mice are trained to navigate a virtual corridor while recording the same hippocampal neurons via chronic 2-photon calcium imaging before and after stroke for up to six w
ePoster · Neuroscience