Reduction of entropy specific to cortical outputs during anesthetic-induced loss of consciousness
Arjun Bharioke,Martin Munz,Emilie Mace,Botond Roska,Alexandra Brignall,Georg Kosche,Max Ferdinand Eizinger,Nicole Ledergerber,Daniel Hillier,Brigitte Gross-Scherf,Karl-Klaus Conzelmann · COSYNE 2022
Understanding the circuit mechanisms underlying the loss of consciousness during general anesthesia is a long-standing question. Activity within cortex drives conscious perception and, hence, the loss of consciousness is thought to result from the disconnection of cortex from subcortex. Here, we identify a change in the correlation structure of neuronal activity during general anesthesia, specific to the primary population of cortical output neurons. We demonstrate that this increased correlation reduces the information output from cortex, suggesting a mechanism for the loss of consciousness.
Sat, Mar 19, 2022