Topic: neuropil

The entorhinal cortex (EC) plays a pivotal role in memory functions and spatial navigation, connecting the hippocampus with the neocortex. This brain region integrates a wide range of cortical and subcortical inputs and it is one of the first brain regions affected by Alzheimer´s disease. However, its synaptic organization in the human brain is largely unknown due to the difficulties involved in studying the human brain via electron microscope techniques. Here, we used Focused Ion Beam/Scanning Electron Microscopy (FIB/SEM) to perform a 3D analysis of the synapses in all layers of the medial E