Impairment of the placenta–cortex transcriptomic signature following prenatal alcohol exposure, leading to dysregulation of angiogenic pathways
Anthony Falluel-Morel, Camille Sautreuil, Maryline Lecointre, Céline Derambure, Carole Brasse-Lagnel, Philippe Leroux, Annie Laquerrière, Gaël Nicolas, Sophie Gil, Daniel D. Savage, Stéphane Marret, Florent Marguet, Bruno J. Gonzalez · FENS Forum 2024
Although alcohol consumption during pregnancy is a major cause of behavioral and learning disabilities, most FASD infants remain late- or even misdiagnosed. Neuroplacentology has emerged as a new field of research focusing on the role of the placenta in fetal brain development. Several studies focusing on the pro-angiogenic factor PlGF have reported that prenatal alcohol exposure (PAE) dysregulates a functional placenta–cortex axis, leading to neurovascular-related defects. Here, we provide the first transcriptomic “placenta–cortex” signature of the effects of PAE on fetal angiogenesis. Whole
ePoster · Neuroscience