Topic: neuroprotective agents

Dementia is characterised by a profound decline in cognitive and behavioural functions, drastically affecting daily life and social interactions. There is a pressing need for novel therapeutic strategies, particularly if these can be repurposed from available medicine – recent research has suggested antidiabetic drugs may have neuroprotective properties, but validation requires translatable pre-clinical models paired with unbiased assessment. Rocky Mountain Laboratory (RML) scrapie is a well-characterised model that mimics many of the hallmarks of neurodegeneration seen in dementia but does no