Investigating the neural ensembles underlying sundowning in an Alzheimer’s disease mouse model
Michelle Jin, Holly C. Hunsberger, Alicia Whye, Simon Ogundare, Nicole Alvarado, Sophia Sorid, Marcos Lanio, Christine A. Denny · FENS Forum 2024
As high as 50% of Alzheimer’s disease patients experience “sundowning”, defined as an increase in severity of neuropsychiatric symptoms, including agitation, confusion, and anxiety selectively in the evening. While such symptoms influence the decision to institutionalize patients, few preclinical models for sundowning exist and its underlying neural mechanisms are unknown. Here, we establish a preclinical model of sundowning by phenotyping the sleep-wake activity cycle in control (Ctrl) and APP/PS1de9 (AD) mice across different ages in male and female mice. Next, we characterized their anxiety
ePoster · Neuroscience