Cognitive comorbidities in young and adult rats with absence seizures
Mariana Neuparth-Sottomayor, Carolina Pina, Tatiana P. Morais, Miguel Farinha-Ferreira, Daniela S. Abreu, Filipa Solano, Francisco Mouro, Mark Good, Ana M. Sebastião, Giuseppe Di Giovanni, Vincenzo Crunelli, Sandra H. Vaz · FENS Forum 2024
Absence seizures (ASs) are brief periods of lack of consciousness, characterized by 2.5-4 Hz spike-wave discharges in the thalamocortical network in the EEG. Together with ASs, 60% of children with ASs show neuropsychological comorbidities, including cognitive and mood impairments, that can be present before the epilepsy diagnosis and even after the seizures are pharmacologically controlled. Since cognitive alteration may be subtle and task-specific, their presence may be confounded by an anxiety-like phenotype, and no study has tested anxiety and memory in the same animal model of ASs. Using
ePoster · Neuroscience