Role of hypothalamic NPGL/NPGM system in energy metabolism
Kenshiro Shikano, Ikuko Morisaki, Ryoko Higa, Hitoshi Teranishi, Takaki Yahiro, Mitsuhiro Yoshimura, Toshikatsu Hanada, Kazuhiro Nakamura, Yoichi Ueta, Reiko Hanada · FENS Forum 2024
Hypothalamus is the center of energy metabolism and feeding behavior, and several hypothalamic neurotransmitters regulate energy homeostasis. Neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM), were discovered as a novel neuropeptide from hypothalamus in 2014, induced obese phenotype owing to increased feeding behavior and lipogenesis in rats. However, the mechanisms of energy metabolism mediated by NPGL/NPGM system has not been totally elucidated. To investigate the loss of function of NPGL/NPGM system in mammals, we have established NPGL and NPGM double knockout mice (NPGL
ePoster · Neuroscience