Restorative potential of ciliary body cells in a retinal ganglion cell degeneration model
Marta Fernandez Nogales, Fernando Lucas Ruiz, F. Javier Valiente Soriano, Macarena Herrera, Francisco M. Nadal Nicolás, Marta Agudo Barriuso, Eloisa Herrera · FENS Forum 2024
The peripheral area of the adult mammalian retina, known as the ciliary body (CB) has been proposed as a niche of neural stem cells because, in vitro, cells from this area are able to form neurospheres, proliferate and differentiate. Here, we explore the potential of CB cells to differentiate and replace degenerated retinal ganglion cells (RGCs) in vivo. CB cells isolated from adult retinas and intravitreally injected into the retina of mice that had been previously depleted of RGCs by optic nerve axotomy, integrate into the ganglion cell layer and express neuronal markers. A different type of
ePoster · Neuroscience