Topic: Neurotoxicology

In vitro neuronal models are valuable tools for studying neural diseases and neurotoxicology. With the use of microelectrode arrays, the Maestro Pro can measure the electrical activity of neural cultures in a high throughput, label-free manner. Here, an optimized in vitro assay is demonstrated to characterize the response of neural cultures to neuroactive compounds. 40,000 primary cortical rat neurons per well were plated on CytoView 24-well plates, and neural activity and viability were monitored on the Maestro Pro. To determine the optimal culture conditions for compound dosing, neural netwo