Leptin regulates the development of glutamatergic synapses in the developing hippocampus through the proteases matrix metalloproteinase 9 and cathepsin B
Jose Luis Rodriguez Llamas, Crystal Dillon, Gary Wayman · FENS Forum 2024
Neurotrophic factors direct the development of the nervous system, and impairments in their function lead to neurological disorders. Leptin is an adipokine that exerts neurotrophic effects in the hippocampus, promoting synaptogenesis and synaptic plasticity. Meanwhile, rodents with altered leptin signaling exhibit impairments in these processes and defects in hippocampal-related functions. Leptin increases mushroom spines and the frequency of mini excitatory postsynaptic currents (mEPSCs) in developing hippocampal neurons, evidencing increased functional glutamatergic synapses. Given the presu
ePoster · Neuroscience