Topic: neurotrophic signalling

Accumulating evidence indicates that the plasticity-inducing effects of conventional antidepressant drugs are mediated by their direct binding to TrkB. In addition, it has recently been reported that psychedelics LSD and psilocybin, also bind to TrkB with higher affinity than antidepressants. In this study, we investigated whether psychedelics and classical antidepressants promote TrkB dimerization and neurotrophic signalling in a differential manner. The effects of psychedelics on the TrkB dimerization dynamics and neurotrophic signalling associated with plasticity were studied treating N2a c