Topic: neurovascular cross-talk

Sturge-Weber syndrome (SWS), a rare neurovascular disorder associated with a GNAQ gene mutation, presents distinct clinical features, including a facial port-wine birthmark, glaucoma, and various neurological symptoms. Despite these characteristics, the molecular complexity of neurovascular cross-talk remains poorly understood. This study aims to unravel Gαq regulation in neural cells, focusing on surface marker expression. To study surface marker regulation, CRISPR-mediated Gαq knockouts were generated in Lund human mesencephalic cells (LUHMES; neural) and pluripotent stem cells (embryonic).