Attempt to pharmacologically induce neurovascular uncoupling in aged, experienced rats
Bence Tamás Varga, Attila Gáspár, Aliz Judit Ernyey, Barbara Hutka, Tekla Brigitta Tajti, Levente Kollár, Péter Kovács, Zoltán Sándor Zádori, István Gyertyán · FENS Forum 2024
Animal models of neurovascular uncoupling (NVU) would be important tools for developing drugs in neurodegenerative disorders. Pharmacologically induced NVU was established in mice [Tarantini et al., 2015] but only preliminary results are available in rats [Varga et al., 2022]. In the current study we attempted to evoke NVU in a translationally relevant rat population.We used 28-month-old male Long-Evans rats with learning history and stable performance in 5-choice serial reaction time task (5-CSRTT). Morris water-maze (MWM), pot jumping, and touchscreen pairwise discrimination. NVU was induced
ePoster · Neuroscience