In vitro pharmacological characterization of ligands of the growth hormone secretagogue receptor (GHSR) using the dynamic mass redistribution and calcium mobilization assays
Chiara Ruzza, Chiara Sturaro, Federica Ferrari, Pietro Pola, Michela Argentieri, Barbara Bettegazzi, Stefano Cattaneo, Claudio Pietra, Davide Malfacini, Girolamo Calò · FENS Forum 2024
Ghrelin modulates several biological functions via selective activation of the growth hormone secretagogue receptor (GHSR). GHSR agonists may be useful for the treatment of anorexia and cachexia while antagonists and inverse agonists may represent innovative options for the treatment of drug addiction. Thus, the identification and pharmacodynamic characterization of new GHSR ligands is of high interest. In the present work the label-free dynamic mass redistribution (DMR) assay has been used to evaluate the pharmacological activity of a panel of GHSR ligands, already reported in the scientific
ePoster · Neuroscience