Reducing GABA A receptor activation through bicuculline treatment improves neuroinflammation in cerebellum of hyperammonemic rats
Andrea Palomares Rodriguez, Yaiza M. Arenas, Vicente Felipo · FENS Forum 2024
GABAergic neurotransmission is enhanced in the cerebellum of hyperammonemic rats, an animal model of hepatic encephalopathy, and this induces motor incoordination. There is an interplay between neuroinflammation and GABAergic neurotransmission, but the underlying mechanisms remain unclear. This work aimed to unveil the molecular mechanisms by which GABAergic neurotransmission modulates neuroinflammation in the cerebellum.Ex-vivo experiments were performed using cerebellar slices from control and hyperammonemic rats treated or not with bicuculline. We analyzed by immunohistochemistry microglia
ePoster · Neuroscience