Synaptic neurofilaments changes during aging and the effect of environmental enrichment
Elisa Principi, Marta Balietti, Giorgia Fattorini, Fiorenzo Conti · FENS Forum 2024
Neurofilaments, neuron-specific cytoskeletal proteins, are heteropolymers composed of four subunits: NFL, NFM, NFH, and αINTX. The synaptic population (SNFs) differs from the axonal subgroup and subserves unique functions, such as the maintenance of synaptic integrity and the modulation of neurotransmission. During aging, synapses undergo several modifications, contributing to the worsening of cognitive performances and the so-called age-related memory impairment. Despite that, nothing is known about "senescent" SNFs. Our research aimed to study the age-related expression pattern of SNFs subun
ePoster · Neuroscience