Cannabinoid CB1 receptors in oligodendrocytes: Modulation of energy metabolism and autoimmune demyelination
Ester Sanchez, Ana Bernal-Chico, Aitziber Uribe, Teresa Colomer, Carmen Utrilla, Andrés Mateo Baraibar, Asier Ruiz, Tania Aguado, Manuel Guzman, Ismael Galve-Roperh, Javier Palazuelos, Susana Mato · FENS Forum 2024
Oligodendrocytes produce central nervous system myelin and provide metabolic support to axons. Myelin formation and repair are energetically expensive and oligodendrocyte metabolic defects have been postulated as a cause of neurodegeneration. Endocannabinoids modulate neuronal and astroglial metabolism and attenuate inflammatory demyelination in multiple sclerosis (MS) through the activation of CB1 receptors (CB1Rs). Myelinating oligodendrocytes and precursor cells (OPCs) express CB1Rs that mediate protection from excitotoxicity and promote lineage progression but the metabolic implications of
ePoster · Neuroscience