Early life adversity and the impact of glucocorticoids on NG2-glia: A potential mechanism for stress-related psychiatric disorders
Katrin Becker, Lorenzo Mattioni, Maja Papic, Andrea Conrad, Beat Lutz, Ari Waisman, Michael J. Schmeisser, Marianne B. Müller, Giulia Treccani · FENS Forum 2024
Early life adversity (ELA), defined as an adverse experience during critical periods in brain development, is a risk factor for neurodevelopmental and psychiatric disorders. The major effector molecules of stress are glucocorticoids (GCs), which by binding to glucocorticoid receptors (GRs) regulate several biological processes in the brain and the body. So far, little is known about the effects of ELA on a subtype of glial cells, named oligodendrocyte precursor cells (OPCs) or NG2-glia. To investigate how GCs can affect the molecular signature of the NG2-glia and impact the behavioral phenotyp
ePoster · Neuroscience