Modelling MSA disease through the generation of brain organoids
Manuela Magni, Elena Vezzoli, Emanuele Frattini, Ilaria Trezzi, Fabio Biella, Marco Brevi, Francesca Longhena, Arianna Bellucci, Stefano Ferrero Bogetto, Andrea Falqui, Alessio Di Fonzo · FENS Forum 2024
Multiple System Atrophy (MSA) is a progressive neurodegenerative disorder due to the loss of various neuronal populations, including the GABAergic and the dopaminergic systems in the striatum and in the midbrain. The resulting degeneration of the nigro-striatal circuit is responsible for a severe neurological involvement characterized by parkinsonism and cerebellar phenotypes. The neuropathological hallmarks of MSA consist of alpha-synuclein aggregations in oligodendrocytes and neurons. No disease-modifying therapy is available for this disorder, resulting in a reduced life-span of affected pa