Non-canonical anti-inflammatory effects of sitagliptin, a drug for type 2 diabetes, in microglia
António Francisco Ambrósio, Cristiana Leote, Sandra Correia, Lucia Bufano, Beatriz Fazendeiro, Paulo Fernando Santos, Raquel Boia, Ana Raquel Santiago, Rosa Fernandes, Hélène Léger · FENS Forum 2024
Sitagliptin, used for type-2 diabetes, inhibits dipeptidyl peptidase 4 (DPP-4), thus increasing insulin secretion. We found that sitagliptin protects the retina of diabetic animals, including type-1 diabetic animals, inhibiting nitrosative stress and neuroinflammation. We also showed that microglia-mediated neuroinflammation triggers retinal degeneration. Here, we investigated whether sitagliptin effects can be due to a direct inhibition of microglia reactivity, mediated by DPP-4 blockade, or if pleiotropic mechanisms can be involved. Primary mixed and organotypic rat retinal cell cultures and
ePoster · Neuroscience