Topic: NK3 agonist

According to the literature low body temperature is considered a risk factor for Alzheimer’s disorder (AD) and may contribute to a significant worsening of its histological pathology. Less is known about the alteration of the thermoregulation in AD subjects. Therefore, our aim was to identify it in the popular triple transgenic mouse model (3xTg-AD) of AD.In addition to continuous telemetric monitoring of circadian temperature changes, we used cold and warm stimulations as well as an NK3 agonist (senktide)-induced drop in core body temperature modelling post-menopausal heat waves. Six-month-ol