Morphological and physiological features of chandelier cells in the prefrontal cortex in two transgenic mouse lines
Zsuzsanna Fekete, Petra Nagy-Pál, Zsófia Reéb, Judit Veres, Norbert Hájos · FENS Forum 2024
Chandelier cells (ChCs) that are present only in cortical structures selectively form synapses on the axon initial segments (AISs) of principal neurons (PNs) – the site of action potential generation. Therefore, these GABAergic cells are in the position to control the spiking of their postsynaptic partners in the most powerful way. Here, we compared anatomical and electrophysiological features of ChCs sampled in the medial prefrontal cortex (mPFC) of the Nkx2.1-Cre and PVeGFP mouse lines.By performing whole-cell recordings from ChCs in acute prefrontal cortical slices, we found that ChCs label
ePoster · Neuroscience