Combining on-cell patch clamp with localized muscimol puffing to reveal electrophysiological abnormalities in transgenic rat models of ASD
Nicola Verda, Zubin Rashid, Erwin van den Burg, Sumantra Chattarji, Ron Stoop · FENS Forum 2024
Autism spectrum disorder (ASD) is a term used to describe a wide variety of neurodevelopmental disorders that share manifestations and symptoms including intellectual disabilities, social impairments, delayed speech development and repetitive behaviors. Different animal models of ASD share similar electrophysiological and morphological aberrations at the neuronal level. In particular, previous studies have shown that the developmental maturation of GABAergic circuitry appears altered leading to an excitation/inhibition imbalance in the adult. During neurotransmission, the polarity of the GABAe
ePoster · Neuroscience