Lhx4 surpasses Lhx3 to promote the differentiation of spinal V2a interneurons
Estelle Renaux, Charlotte Baudouin, Damien Marchese, Yoanne Clovis, Younès Achouri, Lin Gan, Soo-Kyung Lee, René Rezsohazy, Frédéric Clotman · FENS Forum 2024
Locomotion is controlled by Central Pattern Generators that elicit rhythmic locomotor movements of the limbs. These circuits located in the ventral part of the spinal cord are composed of motor neurons and interneurons. In the developing spinal cord, transcriptional regulators, including Lim-Homeodomain (Lim-HD) transcription factors, cooperate to segregate motor neurons and different interneuron subsets with distinct molecular, morphological, and functional characteristics. Based on their high sequence homology and their similar distribution, Lim-HD paralogs of the Lim3 group (Lhx3 and Lhx4)
ePoster · Neuroscience