NLRP1 inflammasome activation in schizophrenia
Ena Spanic Popovacki, Dora Vogrinc, Heidi Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopic, Klara Pintaric, Mirjana Babic Leko, Mihaela Pravica, Zeljka Krsnik, Darko Marcinko, Marina Sagud, Patrick Hof, Mihovil Mladinov, Goran Simic · FENS Forum 2024
Aims: In the context of the maternal immune activation and neuroinflammation hypotheses of schizophrenia (SZ), we studied NLRP1 mRNA and protein expression in the postmortem brain tissue from a total of 10 SZ and 10 controls. Methods: RNA underwent reverse transcription and was hybridized onto the Affymetrix HG-U133 Plus 2.0 array, using the same protocol as the GeneChip Human Exon 1.0ST Arrays (Affymetrix, Santa Clara, CA, USA), which examines over a million exons, spanning 17,868 NCBI RefSeq transcripts. Brain tissue samples were embedded in paraffin, cut into 12 μm-thin sections, and subjec
ePoster · Neuroscience