ePoster · Neuroscience
Minocycline rescue selectively hippocampus mGluR1/5-LTD in adolescent rat after repeated ethanol exposure
Olivier Pierrefiche, Margot Debris, Chloé Deschamps, Mickael Naassila · FENS Forum 2024
Binge drinking (BD) consists in high and rapid episodes of ethanol consumption interspaced with abstinence. Studies in adolescent rats showed that history of BD during this period of brain maturation impair memory on the long-term. However, the mechanisms of these effects remain unclear. Others and we found that pre-treatment with minocycline, an antibiotic with anti-inflammatory properties prevented some of the negative effects of BD on hippocampus long-term synaptic depression (LTD) and learning behaviour. However, whether NMDA- and mGlu-LTD are similarly affected, and which of these forms o