Topic: NMDA receptor ablation

Although the aetiology of schizophrenia is still not thoroughly understood, post-mortem studies of patients have consistently revealed alterations of GABAergic interneurons, particularly lower levels of GAD67 and parvalbumin in cortical parvalbumin interneurons (PVs). A deficient maturation of PVs could relate to the neurodevelopmental aspect of schizophrenia since normal wiring of cortical circuits relies on this process. We have previously shown that mice with an early postnatal NMDA receptor ablation in corticolimbic GABAergic interneurons –predominantly PVs– present schizophrenia-like phen