Topic: NMDA receptor antagonists

NMDA receptor antagonists, such as MK801, produce hyperlocomotion and affect the dopamine (DA) system by increasing ventral tegmental area (VTA) activity and enhancing DA release in many regions of the rat brain. NMDAR antagonists also enhance the power of high-frequency oscillations (HFO) in cortical and subcortical areas. The olfactory bulb (OB), a generator of NMDAR-enhanced HFO, contains DA receptors (D1R/D2R) and periglomerular DA neurons. However, the role of DA in the OB in the modulation of MK801-enhanced HFO and locomotion is unknown. Selective DA agonists (SKF38393, quinpirole) and a