Neuro-immunobiology in a mouse model of anti-NMDAR encephalitis and assessment of treatment approaches
Estibaliz Maudes, Jesús Planagumà, Laura Marmolejo, Radosevic Marija, Ana Beatriz Serafim, Jon Landa, Mar Guasp, Marianna Spatola, Lidia Sabater, Carlos Sindreu, Carlos Matute, Josep Dalmau · FENS Forum 2024
Anti-NMDAR encephalitis (NMDARe) is a disorder mediated by antibodies against the GluN1 subunit of NMDAR. Patients develop severe neuropsychiatric symptoms that usually improve with immunotherapy, although very slowly. To better understand the neuro-immunobiology of the disease and how different treatments might work, we aimed to develop an animal model that reproduced most of the symptoms and their protracted clinical course. Eight-week-old female mice (C57BL/6J) were immunized (days 1 and 28) with GluN1356-385 peptide or saline with AddaVax adjuvant and Pertussis Toxin. After developing symp
ePoster · Neuroscience