Impaired memory storage and recall in a hippocampal CA1 network in early Alzheimer’s disease
Saana Seppälä, Fabio Librizzi, Marja-Leena Linne, Justinas Dainauskas, Hélène Marie, Michele Migliore, Ausra Saudargiene · FENS Forum 2024
Alzheimer’s disease (AD) has wide-ranging health and economical impact affecting millions globally. The molecular mechanisms behind AD are not yet understood, but alterations in the processing and clearance of Amyloid precursor protein (APP), such as increased levels of specific APP fragments like Amyloid-ß peptide (Aß), have been observed in early-stage AD. Increased Aß concentration leads to impaired long-term potentiation (LTP) at hippocampal CA1-CA3 synapses, the process that can be restored by partially blocking GluN2B-NMDA receptor (Ronicke et al., Neurobiol. Aging 2011). We modeled comp
ePoster · Neuroscience