Topic: NMDAR loss

Strategy updating is one of the recent roles assigned to the retrosplenial cortex (RSC). Studies have shown that lesions or inactivation of RSC cause impairment in exploring and learning new alternative options when previous ones were available but no longer appropriate, suggesting its importance for set-shifting behaviors1. Building on previous evidence of impaired reversal learning in 6-month-old 5xFAD mice2, this study focuses on uncovering the synaptic correlates of reversal learning in the RSC in the context of AD. Therefore, we use a set-shifting task that challenges the animals to devel