Blood D-serine levels correlate with aging and dopaminergic treatment in Parkinson's disease
Isar Yahyavi, Alberto Imarisio, Micol Avenali, Anna Di Maio, Gabriele Buongarzone, Caterina Galandra, Marta Picascia, Asia Filosa, Gasparri Clara, Maria Cristina Monti, Mariangela Rondanelli, Claudio Pacchetti, Francesco Errico, Enza Maria Valente, Alessandro Usiello · FENS Forum 2024
Parkinson’s disease (PD) is a progressive condition resulting in dopaminergic nigrostriatal neuronal death. Several evidence suggest that beyond dopaminergic system other neurotransmitters are involved in PD. In particular, molecular alterations occurring at ionotropic N-methyl-D-aspartate receptors (NMDARs) contribute to appearance of the disease features. Among neurotransmitters involved in glutamatergic system, D-serine (D-Ser) plays a crucial role acting as NMDARs co-agonist. A previous study carried out on preclinical models of PD, showed increased levels of D-Ser as well as of its metabo
ePoster · Neuroscience