Inhibition of glial scar formation after spinal cord injury in Noggin conditional knockout mice and by anti-Noggin antibody treatment
Satoru Yamagishi, Shuo Li, Yuki Wakayama, Juntan Li, Yibo Han, Yashuang Ping, Hideyuki Arima, Kohji Sato, Yukihiro Matsuyama · FENS Forum 2024
Noggin is a glycosylated protein that can act as an inhibitor of bone morphogenetic protein (BMP) and has been shown in animal studies to improve functional recovery after spinal cord injury (SCI). Its mechanism of action promotes the regeneration and repair of damaged spinal cord tissue by regulating the differentiation and growth of glial cells and regulates the interaction between neurons and glial cells. However, very few studies on endogenous Noggin have been reported, and the available studies are limited to the therapeutic effects of exogenous Noggin. Therefore, we explored the expressi
ePoster · Neuroscience