Topic: noise-induced hearing loss

The Kumar Lab in the Department of Otolaryngology at Washington University in St. Louis runs an NIH-funded program on the cortical cellular and circuit mechanisms behind hearing difficulty in noisy environments after noise-induced hearing loss, integrating systems neuroscience, genetics, pharmacology and computational approaches. Methods include in vivo two-photon imaging of identified neuronal populations in awake mice, auditory behavioral assays, ex vivo brain-slice imaging and electrophysiology, chemogenetic and optogenetic circuit manipulation, inducible conditional knockout mice and pharm