The ability of ellagic acid loaded in nanovesicles to rescue the Aβ-induced LTP impairment
Nunzia Maisto, Dalila Mango, Sepideh Dashtiani, Federica Rinaldi, Robert Nisiticò · FENS Forum 2024
Ellagic acid (EA) is a natural compound characterized by neuroprotective potential, although it shows poor pharmacokinetic profile. A valid approach could be delivering the drug in non-ionic surfactant vesicles (NSVs) through the nose to brain (N2B) route. Our aim was to load EA inside NSVs and explore EA-NSVs capability, compared to free-EA, to restore the impairment induced by Aβ1-42 on synaptic plasticity through electrophysiological recordings in ex-vivo model.Empty and loaded NSVs were prepared, and a physicochemical characterization were carried out. We performed field and whole cell pat
ePoster · Neuroscience