Topic: non-linear filtering

Model fitting methods have been widely used in neuroscience to infer the parameters of a biophysical system from its responses to experimental stimulations. For instance, the parameters of a chemical synapse (e.g. the number of presynaptic vesicles, or its depression time constant) can be estimated from its postsynaptic responses to evoked stimuli. However, these estimates critically depend on the stimulation protocol being used. Experiments are often conducted with non-adaptive stimulation protocols that may not yield enough information about these parameters. Here, we propose using Bayesian