Assessing the therapeutic impact of a 7-day N-acetylcysteine treatment in a preclinical model of Parkinson's disease: Behavioral and molecular insights
Rita Caridade, Bruna Araújo, Ana Catarina Vilaça-Ferreira, Catarina Teixeira, Joana Martins-Macedo, Carla Soares-Guedes, Hugo JR Fernandes, Richard Wade-Martins, FG Teixeira · FENS Forum 2024
Promising alternative strategies, such as repurposing drugs, have been considered for Parkinson’s Disease (PD). Within this framework, N-acetylcysteine (NAC) has shown promising results in preserving the dopaminergic system. Indeed, published data from our group revealed that NAC single-dose administration enhanced DAn viability, as we found that it could restore dopamine transporter (DAT) levels. With this in mind, we consider that NAC application could be a remarkable asset to approach PD. Therefore, in the present study, we addressed the impact of a 7-day treatment with NAC in a 6-hydroxydo
ePoster · Neuroscience