Post-treatment approach for hypoxia and ischemia: Selective targeting of non-nuclear estrogen receptors signaling pathway inhibits neurotoxicity and apoptosis
Andrzej Łach, Karolina Przepiórska-Drońska, Bernadeta A. Pietrzak-Wawrzyńska, Małgorzata Kajta, Agnieszka Wnuk · FENS Forum 2024
The aim of this study was to address the urgent global need for an effective therapeutic strategy against acute stroke and perinatal asphyxia. A promising answer to limitations of currently existing therapies might be the newly designed Pathway Preferential Estrogen-1 (PaPE-1). Estrogen receptor-mediated signaling is pivotal for neuroprotection, and its impairment during hypoxia/ischemia may increase the risk of cerebral infarction. Our goal was to selectively activate non-nuclear estrogen receptors signaling, providing a wide therapeutic window and minimizing adverse hormonal effects associat
ePoster · Neuroscience