Screening AAV delivery routes, capsids, and promoters for cortex-wide functional and long-term stable access to brain function in large-brain species
Fanni Somogyi, Beatrix Kovacs, Klaudia Csikos, Abel Petik, Domonkos Horvath, Attila B. Dobos, Lucia Wittner, Daniel Hillier · FENS Forum 2024
How signals relevant to behavior and cognition are processed within neural circuits, engaging thousands of neurons across multiple brain regions remains a central question. After decades of research, our current understanding of brain-wide neural circuits enabling various brain functions in non-rodent species (e.g., cats and primates) remains limited. In stark contrast, significant progress has been made in dissecting mouse brain function, enabled by the availability of transgenic driver and reporter lines.We set out to emulate the quality and reproducibility of transgenic mouse reporter lines
ePoster · Neuroscience