Topic: non-steroidal anti-inflammatory analgesic

Carprofen is a commonly used non-steroidal anti-inflammatory analgesic, but data on pharmacokinetics and analgesic efficacy after neurosurgical interventions are limited. This study aimed to evaluate a carprofen-based analgesic regimen for craniotomies by monitoring plasma concentrations and physiological parameters.Sprague-Dawley rats (n=6) underwent subcutaneous transmitter implantation for heart rate and activity monitoring. Intracerebral 6-OHDA injection was conducted, and six weeks later depth electrodes were implanted. Oral carprofen treatment (10 mg/kg/24h) started the day prior to surg