Phenotypic characterization of nociceptin/orphanin FQ receptor knockout mice (NOP(-/-)) in different in vivo models of migraine and evaluation of the NOP receptor as a treatment target
Chiara Sturaro, Alessia Frezza, Pietro Pola, Michela Argentieri, Nurulain Zaveri, Girolamo Calò, Chiara Ruzza · FENS Forum 2024
Migraine is a pain disorder that affects 10 – 15% of the population worldwide. Even though there is a wide choice of therapeutics that includes different classes of well-tolerated drugs, numerous patients are still not satisfied with their treatment. Trigeminal ganglion and nucleus caudalis are enriched with nociceptin/orphanin FQ (N/OFQ) receptor (NOP)-expressing cells. The general aim of the present study is to investigate the role of the N/OFQ – NOP system in the modulation of migraine. This study evaluated the phenotype of mice with genetically induced knockout of the NOP receptor gene (NO
ePoster · Neuroscience