Topic: noradrenergic activity

Dopaminergic and noradrenergic activity increases in response to salient environmental stimuli to mediate similar behavioral functions. However, mechanistic insight into such overlap is poorly understood. Recently, we demonstrated that phasic dopamine (DA) release in the nucleus accumbens (NAc) is modulated by adrenergic receptors in the VTA to facilitate stimulus-dependent behaviors. However, it remains to be demonstrated what kinds of stimuli induce noradrenergic modulation of VTA-NAc circuit. We aimed to determine which stimuli are able to evoke noradrenergic signaling in the VTA to modulat