Monoaminergic modulation of microglia in physiological and inflammatory conditions
Moritz Brosch, Bruno Benedetti, Viktor Lippert, Marco Zattoni, Sofia Chanel Weinbender, Ariane Benedetti, Lara Bieler, Günter Lepperdinger, Ludwig Aigner, Sebastien Couillard-Despres · FENS Forum 2024
The activity of microglia, the resident immune cells of the central nervous system (CNS), is controlled by various neurotransmitters and modulators. For instance, monoamines such as serotonin (5-HT) and norepinephrine (NE), have been reported to modulate the physiological functions of microglia. However, altered concentrations of monoamines have been observed in pathologies of the CNS, such as Alzheimer's disease or major depressive disorder. Remarkably, changes in monoamine levels happen in synchrony with altered microglial functions during CNS diseases. Thus, a reduced immune modulation thro
ePoster · Neuroscience