Topic: normoxia

Cell culture is a fundamental experimental tool for understanding cell physiology. However, translating these findings to in vivo settings has proven challenging. Replicating donor tissue conditions, including oxygen levels, is crucial for achieving meaningful results. Nevertheless, oxygen culture conditions are often overlooked, particularly in the context of chemotherapy-induced neurotoxicity. In this study we want to investigate the role of oxygen levels in primary neuronal cultures by comparing neuron performance under cisplatin exposure (1 µg/ml) in normoxia (representing atmospheric cond