TRIP6 regulates neural stem cell maintenance through the Notch pathway in the postnatal mammalian subventricular zone
Chia Chi Chung, Xiu Li Yang, Tsu Wei Wang · FENS Forum 2024
Adult neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) pathway in the mammalian brain persists throughout life. An adaptor protein, thyroid hormone receptor interacting protein 6 (TRIP6) is required for self-renewal and proliferation and inhibits neuronal differentiation in neural stem cells (NSCs) of the SVZ. Notch signaling pathway is also necessary for NSC self-renewal and inhibits their neuronal differentiation. Furthermore, we find that TRIP6 activates the Notch signaling pathway. However, the mechanism underlying this process remains to be elucidated. Here, we performed
ePoster · Neuroscience