The role of maternal and paternal genomes in neuronal network assembly, dynamics, and circadian rhythms
Alessia Polito, Angelo Serani, Robert Wolff, Alice Melloni, Gianluca Como, Elisa Gelli, Michela Chiappalone, Valter Tucci · FENS Forum 2024
Genomic imprinting controls fundamental brain functions in the 24-hour, including circadian rhythm, which is formed along with corticogenesis in early development. However, how imprinted genes regulate these crucial processes in mammals remains elusive. In this study, we investigated the contribution of the maternal or paternal genomes in cortical development and the maintenance of the circadian clock, focusing on the transition from individual cells to a comprehensive neuronal network. To this aim, we used androgenetic (AG) and parthenogenetic (PG) mESCs, generating models with increasing com
ePoster · Neuroscience